| abstract |
It is in benzene, at 80 DEG C the invention discloses a kind of method of indoles double carbonylation, using α hydroxy-ketones and indoles as reaction raw materials, using oxygen as oxidant, in the presence of copper catalyst, reaction obtains double carbonyl Benzazole compounds shown in formula (III).Advantage of the present invention includes：Reaction is efficient, and yield is higher；Oxygen is used as oxidant；Reaction condition is gentle, without strong acid and strong base；Cheap metal is catalyzed；Reaction substrate is easily prepared；It can also be realized after reaction amplification. |