| abstract |
The invention belongs to the technical field of organic synthesis, and specifically discloses a novel gossypol derivative and its preparation method and application. The present invention uses gossypol and isonitrile as raw materials, stirs and reacts at 70-80°C for 24-36h in a polar solvent, then simply filters and separates, and prepares a series of gossypol derivatives with modified aldehyde groups in one-step reaction . The synthesis method and post-treatment used in the present invention are extremely simple, and the reaction system is very mild. The synthetic novel gossypol derivatives retain the unique active phenolic hydroxyl groups of gossypol to the greatest extent, and are expected to retain all the excellent biological activities of gossypol. The problem of the toxic aldehyde group carried by gossypol is solved. Most gossypol derivatives prepared by the invention have good anti-prostate cancer activity and can be applied in the field of anti-tumor. |