http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104804099-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 |
| filingDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104804099-B |
| titleOfInvention | A kind of reinforced polyepitope vaccines of recombination H9N2 subtype avian influenza |
| abstract | The present invention relates to a kind of preparation and application of recombination H9N2 subtype avian influenza (Avian influenza (H9N2), AI) reinforced polyepitope vaccines.The vaccine is using neutralizing epitope, Th epitope, CTL epitope and the B cell epitope of H9N2 subtype avian influenza virus major structural protein hemagglutinin (HA), neuraminidase (NA), nucleocapsid protein (NP) and stromatin 2 (M2) as vaccine frame structure, by connecting again with cell factor fowl interleukin 18 (chIL-18) after flexible linker connection, Escherichia coli are converted after being cloned into pRSETB carrier, through techniques such as everfermentation, purifying, emulsifications, the reinforced polyepitope vaccines of bird flu with Desirable immunogenic are obtained.Animal experiments show that recombinating the reinforced polyepitope vaccines of H9N2 subtype avian influenza not only good security, but also effective humoral immunity and cell immune response can be excited. |
| priorityDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 281.