| abstract |
The invention discloses a compound of formula (I), wherein: X is O or -NR 3 ; R 1 is -CH 2 CH 2 CH 3 , -CH 2 CF 3 , -CH 2 CH 2 CF 3 , -CH 2 CF 2 CH 3 , -CH 2 CH 2 CH 2 CF 3 , -CH 2 CH 2 CF 2 CH 3 , -CH 2 CH(CH 3 )CF 3 , -CH 2 CH 2 CH 2 F, or -CH 2 (cyclopropyl ); R 2 is -CH 2 CH 2 CH 3 , -CH 2 CF 3 , -CH 2 CH 2 CF 3 , -CH 2 CF 2 CH 3 , -CH 2 CH 2 CH 2 CF 3 , -CH 2 CH 2 CH 2 F, -CH 2 CH(CH 3 )CF 3 , -CH 2 CH 2 CF 2 CH 3 , -CH 2 (cyclopropyl), -CH(CH 3 ) (cyclopropyl), phenyl, fluoro Phenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, pyridyl, formula (i), formula (ii), formula (iii), formula (iv) or formula (v); Ring A is phenyl or pyridyl; and R 3 , R a , R b , R c , y and z are as defined herein. The invention also discloses a method for inhibiting Notch receptors using such compounds, and compositions comprising such compounds. These compounds are useful in treating, preventing or slowing the progression of diseases or disorders, such as cancer, in various therapeutic areas. |