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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-40
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
filingDate 2013-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-104797276-B
titleOfInvention Bio-orthogonal is used to combine the method to cross-linking bioprosthetic tissue
abstract Describe the method for processing bioprosthetic tissue.The method includes making biological tissue contact with fixed compound, and this fixed compound includes the first and second functional groups.First functional group can be relevant to same biological tissue tissue functional group reactions, and with its coupling.Second functional group is that bio-orthogonal combines centering.The biological tissue being coupled to fixed compound is exposed to connect compound subsequently.Connecting compound and include at least two functional group, each includes that bio-orthogonal combines another of centering.In a preferred embodiment, bio-orthogonal combines being azide and alkynes.The method can perform in the presence of a catalyst, preferably copper catalyst.Alternatively, the method can perform under there is not catalyst, and wherein alkynes is merged in the cyclic compound of ring tensioning, such as cyclooctyne.
priorityDate 2012-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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