http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104788482-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2015-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104788482-B |
| titleOfInvention | A kind of method preparing 2-aminopyrimidine-5-boric acid pinacol ester |
| abstract | The invention discloses a kind of method preparing 2 aminopyrimidine 5 boric acid pinacol esters, from raw material 2 chloropyrimide, at BF 3 ‑Et 2 Under O catalysis, bromo is occurred to obtain 2 chlorine 5 Bromopyrimidines with NBS；This intermediate and n Bu subsequently 3 MgLi 20～10 DEG C of reactions, be subsequently added methoxyl group boric acid pinacol ester or isopropoxy boric acid pinacol ester carry out boronation after obtain 2 chloropyrimide 5 boric acid pinacol esters；It is subsequently added in ammonia or methanolic ammonia solution, after 80～100 DEG C of sealing reactions, obtains 2 aminopyrimidine 5 boric acid pinacol esters.Synthetic technological condition of the present invention is gentle, it is to avoid ultralow temperature reaction, and reacts and can be carried out continuously, and only need to carry out simple recrystallization when end product can get sterling. |
| priorityDate | 2015-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.