http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104788445-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2015-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104788445-B |
| titleOfInvention | A kind of synthetic method of Dasatinib intermediate |
| abstract | The invention belongs to pharmaceutical technology field, a kind of specifically related to synthetic method of 5 thiazole carboxamides of Dasatinib intermediate N (aminomethyl phenyl of 2 chlorine 6) 2 [(pyrimidine radicals of 6 chlorine, 2 methyl 4) amino], specific method is, first under cryogenic, to in aprotic solvent, sequentially add organic base, 2 amino Ns (aminomethyl phenyl of the 2 chlorine 6) formamide of thiazole 5 and 2 methyl 4, 6 dichloro pyrimidines, then rising high-temperature carries out reaction preparation N (aminomethyl phenyl of 2 chlorine 6) 2 [(pyrimidine radicals of 6 chlorine, 2 methyl 4) amino] 5 thiazole carboxamides, compared to existing technology, present invention tool yield higher and the single miscellaneous content of lower maximum, it is adapted to industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299417-A |
| priorityDate | 2015-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.