http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104788361-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-54 |
| filingDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104788361-B |
| titleOfInvention | The synthetic method of the formic acid derivates of 5 azaspiros [2.4] heptane 6 |
| abstract | The present invention provides a kind of synthetic method of the formic acid derivates of (5S) 5 azaspiro [2.4] heptane 6, with 1, 1 the third dimethanol of ring is initiation material, reacted with thionyl chloride, it is oxidized to obtain sulfonate compound, then the imines for being prepared with glycine methyl ester is condensed under potassium tert-butoxide effect, it is acid by regulation system again, alkalescence is treated different things alike and completes hydrolysis, cyclization, amido protecting obtains racemization product, eventually pass fractionation and obtain finished product, total recovery reaches more than 30%, the reaction scheme step is short, the reagent safety used, it is simple to operate, reaction cost is low, yield is higher, suitable industrialized production. |
| priorityDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 159.