abstract |
The invention discloses a synthesis process of 2-amino-4-acetamidoanisole. The process comprises the following steps: in methanol, under the action of an acid-binding agent, carry out the acylation reaction of 2,4-diaminoanisole (III) and acetic anhydride as shown below to obtain the 2-amino -4-Acetamidoanisole (IV); wherein, the molar ratio of the acid-binding agent to 2,4-diaminoanisole is 0.3:1-0.6:1. The synthesis process of the present invention has low energy consumption, low cost, less waste solid and waste liquid, environmental protection, simple operation, mild reaction conditions, high industrial safety factor, and the yield of the target compound is above 86% (based on the initial reaction raw materials) , the HPLC purity is above 99.0%, the yield of the target compound is high, the quality is good, and it is more suitable for industrial production. |