http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104784754-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 |
| filingDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104784754-B |
| titleOfInvention | Silk artificial blood vessel and preparation method thereof |
| abstract | Belonging to the field of biomedical engineering, the invention specifically related to a silk artificial blood vessel and a preparation method thereof. The artificial blood vessel includes a silk woven blood vessel body and glycosylated cross-linking sericin filling blood vessel body fiber gaps. The preparation method includes the steps of: preparation of the blood vessel body, compounding of the blood vessel body and glycosylated sericin, blood vessel surface modification and endothelial pre-coating. In the invention, glycosylated sericin is compounded with silk, then aldehyde is employed to crosslink sericin so as to reduce water solubility, the gaps between artificial blood vessel silk fiber are filled to prevent blood leakage, and the rigidity of the blood vessel is improved. The glycosylated sericin is located on the artificial blood vessel surface, can reduce immunogenicity and improve the anticoagulation effect, and makes the artificial blood vessel difficult to degrade, thus overcoming the two defects of easy degradation and strong immunogenicity in the prior art. And the silk artificial blood vessel has the advantages of simplicity and practicability, good quality and low price. |
| priorityDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.