abstract |
The present invention relates to obeticholic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for treating or preventing a disease or condition mediated by FXR, cardiovascular disease or cholestatic liver disease, and for lowering HDL cholesterol, lowering triglycerides or inhibiting fibrosis in a mammal. The present invention also relates to a synthesis method of obeticholic acid. |