| abstract |
The invention relates to new fatty acid-bile acid conjugates having fat lowering activity and represented by a formula I, non-toxic pharmaceutically-acceptable salts, drug compositions containing the compounds as active components, and uses of the fatty acid-bile acid conjugate, the non-toxic pharmaceutically-acceptable salts, and the drug compositions in fat lowering drug preparation. According to the present invention, in the structure formula I, the bile acid 3-OH is conjugated with the alpha amino of lysine, and then the carboxyl of the fatty acid and the epsilon amino of the lysine form the amide bond, such that the bile acid 24-COOH adopted as the specific bile acid recognition group is retained; and in the structure formula I, R1 represents the following formula, R2 represents the following formula, and n is an integer of 8-22. |