http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104771764-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
| filingDate | 2015-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104771764-B |
| titleOfInvention | A kind of macrophage target carrier system and its preparation |
| abstract | The invention belongs to pharmaceutical field, synthesis and the genes delivery system preparation method of a kind of macrophage targeting vector are disclosed.Macrophage targeting vector is mannose glycosylation protamine, and the electropositive electronegative nucleic acid of mannose glycosylation protamine load forms a kind of nano-particle of lotus positive electricity.The protamine of wherein mannose-modified is prepared through reductive amination process with Protamine by formyl methyl mannopyrane glucosides.Compared with non-viral gene vector protamine, mannose glycosylation protamine is not only with appraising and deciding bit function and with macrophage targeting, can improve gene transfection of the protamine in macrophage and mediate efficiency.Preparation method of the present invention is simple, and technical maturity has a good application prospect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110859817-A |
| priorityDate | 2015-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.