http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104764829-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104764829-B |
| titleOfInvention | What measure fluconazol has related substance and the method for unknown characteristic impurity |
| abstract | What the present invention relates to mensuration fluconazol has related substance and the method for unknown characteristic impurity. It is contemplated that sets up that HPLC method measures fluconazol has related substance, and unknown characteristic impurity is carried out structural identification. The present invention adopts ODS post; With sodium-acetate buffer-methanol for mobile phase A, acetonitrile-methanol is Mobile phase B, gradient elution. The present invention analyzes unknown characteristic impurity followed by LC-MS, then purifies with semi-preparative liquid chromatography separation, determines structure by NMR. Thus, the HPLC Related substance method that the present invention sets up has good Method validation result, compares with Chinese Pharmacopoeia method, and impurity Detection capability is higher; Unknown characteristic impurity is 2-(2,4 difluorobenzene base)-1,3-two (1H-1,2,4-triazol-1-yl)-Ding-2-alcohol. Have been found that the method that the present invention sets up is easy, sensitive, specificity is good, impurity Detection capability strong, can effectively react drug quality. |
| priorityDate | 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.