http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104761474-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-28 |
| filingDate | 2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104761474-B |
| titleOfInvention | A kind of synthetic method of Apremilast chiral amine intermediates |
| abstract | The present invention relates to the synthetic method of a kind of Apremilast chiral amine intermediates (S) 2 [1 (3 ethyoxyl 4 methoxyphenyl)] 1 mesyl 2 ethamine (V).It is characterized in that with 1 (3 ethyoxyl 4 methoxyphenyl) 2 (mesyl) ethyl ketone (I) as raw material, after asymmetric hydrogenation is reduced to mesyl alcohol (II), sulfonyloxy methyl ester (III), Azide (IV), hydro-reduction, obtains the chiral amine intermediates (V) of high chiral purity.This synthetic route is succinct, reaction process is stable, environmental protection and economy, the advantage such as with low cost, and catalytic hydrogenation catalyst amount is few, conversion ratio reaches more than 98%, chiral alcohol can prepare Chiral Amine with extraordinary yield and purity, having good commercial value, also the synthesis for Apremilast chiral amine intermediates opens up a new way. |
| priorityDate | 2015-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.