| abstract |
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful in applications such as gene therapy, large-scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics and regulation of traits in transgenic organisms, Where control over the level of gene expression is desired. An advantage of the present invention is that it provides a means of modulating gene expression and modifying expression levels to suit the needs of the user. |