http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104758952-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G73-0206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G81-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 |
| filingDate | 2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104758952-B |
| titleOfInvention | Nano-carrier of medicine and gene and its production and use is delivered altogether |
| abstract | The invention discloses a kind of nano-carrier of delivering medicine and gene and its production and use altogether；It is specifically related to a kind of while the common delivering nano-carrier TCPL siRNA PPX of load chemotherapeutics and genomic medicine, this delivery system is formed by polymeric prodrugs carrier TCPL, siRNA and multi-functional polyanionic polymer PPX by Electrostatic Absorption self assembly between composition；It can be achieved to be delivered to medicine and gene target into same tumour cell, and siRNA discharged in kytoplasm, the albumen of silence Bcl 2, promote apoptosis and release suppression of the Bcl 2 to Lonidamine；And the chemotherapeutics Lonidamine that mitochondria is acted on is delivered to mitochondria；The apoptosis of the two collaboration triggering mitochondria pathway, kills tumour cell jointly.The present invention passes through In vitro and in vivo activity evaluation, it was demonstrated that the system conveys each one-component better than simultaneously, can significantly improve its active anticancer, with clear and definite synergistic therapeutic effect. |
| priorityDate | 2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.