| abstract |
The invention provides a kind of bacterin preparation and its production and use, the bacterin preparation includes vaccine carrier and antigen component, wherein the vaccine carrier is the vaccine carrier obtained by microorganism through hydrothermal conversion.Bacterin preparation of the present invention is that the vaccine carrier for obtaining microorganism through hydrothermal conversion obtains the bacterin preparation with antigen component compounding.The vaccine carrier material that the present invention is prepared by hydro-thermal reaction, its permeability, hydrophilic and hydrophobic and surface are immunized the properties such as associated ligands density and optimized, so that when it is compounded with antigen component, antigen efficiency of loading improves, so that bacterin preparation has strong immune activation effect, efficiently strengthen Antigen immunogenicity, by body fight original shape into specific immune response, realize for specified disease immunization therapy and prevention.In addition, the raw material sources of bacterin preparation of the present invention are extensive, there is universality on vaccine construction, a variety of bacterin preparations for various disease can be built. |