http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104758244-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0cb011d981829bdcc85a40133a181da8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb14ca098017356fcf0e9e3e92ff64f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e82bf5736c7171419fd68552f650824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b75a8775a7d8a73d0a970624d98ab93c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_084a6c6dcc74043cf4240e1fcc58221a |
| publicationDate | 2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104758244-A |
| titleOfInvention | A nanogel, its preparation method, anti-tumor nanogel drug-loading system and its preparation method |
| abstract | The application provides a nanogel and a preparation method thereof. In the presence of a phenylboronic acid initiator and a morpholine initiator, the L-glutamic acid oligoethylene glycol monomethyl ether ester-N-ring The internal acid anhydride is reacted in an organic solvent to obtain a reaction liquid; the reaction liquid is mixed with L-cystine-N-cyclic internal acid anhydride and L-phenylalanine-N-cyclic internal acid anhydride to react to obtain a nano-condensate glue; it includes phenylboronic acid group, morpholine group, glutamic acid oligoethylene glycol monomethyl ether ester chain link, phenylalanine chain link and cystine link; bonds to form a cross-linked network structure. The invention provides an anti-tumor nano gel drug-carrying system and a preparation method thereof. The surface of the drug-loaded particles has phenylboronic acid and morpholine groups to promote tumor targeting and endocytosis. In the present invention, a nanogel structure is formed through disulfide bond cross-linking, and after targeted enrichment and endocytosis at tumor sites, the drug-loaded particles can rapidly release drugs to achieve the effect of inhibiting tumors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113546061-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113546061-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109966242-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115487155-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109966242-A |
| priorityDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.