| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10152
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24252 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5067 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2019-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-104755606-B |
| titleOfInvention |
Methods and compositions for generating cells with a primary human hepatocyte phenotype |
| abstract |
The present disclosure provides methods and compositions involving in vitro cultures of human hepatocyte cell lines exhibiting primary human hepatocyte phenotypes. Such cell lines are susceptible to infection by hepatotropic viruses such as HCV or HBV and support viral replication and high levels of viral particle production. Such in vitro cultures are useful in the production and study of hepadnaviruses, as well as in screening (eg, antiviral drugs, assessment of drug metabolism) methods, and in the study of primary human hepatocytes. |
| priorityDate |
2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |