abstract |
The present invention relates to novel functionalized 9-bromo-camptothecin derivatives (I), which have cytotoxic activity and are useful in the treatment of diseases such as cancer, cell proliferative disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of using the compounds or pharmaceutical compositions comprising them for treating diseases. The present invention also relates to the use of these functionalized 9-bromo-camptothecin derivatives for the preparation of conjugates. |