| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-64 |
| filingDate |
2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-104744394-B |
| titleOfInvention |
A kind of method of asymmetric synthesis containing trifluoromethyl chirality quaternary carbon compound |
| abstract |
The invention belongs to methodology of organic synthesis technical field, method of more particularly to a kind of asymmetric synthesis containing trifluoromethyl chirality quaternary carbon compound.The inventive method is not using to into catalysis Michael additive reaction; in organic solvent under the catalysis of bisoxazolines chiral ligand and Raney nickel, trifluoromethyl nitro compds and 2 acetyl group azepine aromatics react 3 nitromethyla 1 (2 base of azepine aromatic rings) 1 ketone of fourth of asymmetric synthesis (R) 3 trifluoromethyl.The inventive method reaction yield is high, and optical purity is high.The inventive method can prepare instrument as offer trifluoromethyl quaternary carbon chiral centre compound. |
| priorityDate |
2015-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |