http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104740641-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104740641-B |
| titleOfInvention | A kind of slow control-release microsphere composition of glucose sensitive and preparation method thereof |
| abstract | The present invention discloses a kind of slow control-release microsphere composition and preparation method thereof of glucose sensitive, and the drug for treating diabetes and glucose oxidase (GOD), catalase (POD) are embedded in microballoon together.By taking insulin as an example, when internal concentration of glucose increases, microsphere surface can be diffused into, glucose can be oxidized to gluconic acid by the GOD in ball, and the pH in environment can be reduced to 3 ~ 5 or so, microballoon degradation erosion rate increases sharply, insulin releasing speed is accelerated, and after blood sugar concentration control, pH restores to physiological ph 7.4 or so, microballoon degradation rate reduces, and insulin releasing slows down.When blood glucose increases again, the release behavior of front can be repeated, a kind of release behavior of the self-control of glucose-sensitive is presented in insulin, and POD can be catalytically decomposed hydrogen peroxide and generate oxygen, the oxygen that GOD enzyme reaction consumes in microballoon is compensated for, the active utilization rate of enzyme is improved.Solve the problems, such as that the drug of traditional treatment diabetes cannot carry out self-control release Remedies for diabetes according to internal change of blood sugar. |
| priorityDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 295.