http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104726387-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 |
| filingDate | 2015-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104726387-B |
| titleOfInvention | A kind of attenuated strain of Actinobacillus pleuropneumoniae and the product for preventing porcine pleuropneumoniae |
| abstract | The present invention "an attenuated strain of Actinobacillus pleuropneumoniae and the product for preventing porcine pleuropneumonia" relates to the field of microbiology and immunology. On the basis of the single mutant strain GS7C, the present invention further deletes the ureC gene fragment in the genome, And insert the immunogenic apxIII‑N gene fragment, and then use the sacB gene negative screening system to screen the apxIIC‑/apxIA + and ureC‑ / apxIII + double mutant strains (GS7CA) that successfully express the ApxIII ‑ N protein, The deposit number is CGMCC NO.10016. Experimental data shows that the hemolytic activity and urease activity of the double mutant strain are completely lost, the virulence is greatly reduced, and it can be inherited stably. Low, with cross-protection activity, high biological safety, stable quality. |
| priorityDate | 2015-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.