http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104725628-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-336 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-334 |
| filingDate | 2014-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104725628-B |
| titleOfInvention | A kind of single functionalization branched polyethylene glycol, preparation method and its bio-related substance containing degradable group |
| abstract | The present invention discloses the bio-related substance (formula 2) of a kind of single functionalization branched polyethylene glycol (formula 1) containing degradable group, preparation method and its modification.Wherein, U is trivalent branched groups；n 1 、n 2 、n 3 For the degree of polymerization of PEG chains；Three PEG chains are each independently polydispersity or monodispersity；A 1 、A 2 For C 1‑20 Alkyl；L 1 、L 2 、L 3 、Z 1 For linking group；q 1 For 0 or 1；R 01 For functional groups or its by forms of protection；D is the residue of bio-related substance；L 4 For R 01 The linker formed after being reacted with bio-related substance；The R of formula (1) 01 Outside part contain at least one group that can be degraded under light, heat, enzyme, redox, acidity or alkaline condition.The medicine of the single functionalization branched polyethylene glycol modification containing degradable group, can under given conditions degrade, discharge the drug molecule of high activity, improve pharmaceutical activity and drug effect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11786599-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11554097-B2 |
| priorityDate | 2014-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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