http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104725367-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104725367-B |
| titleOfInvention | The ketoxime medicine of tetrahydro benzothiazol 7, preparation method and applications |
| abstract | The present invention relates to the oxime compound of tetrahydro benzothiazol 7, the structural formula of the medicine includes the cis-isomer and transisomer of the ketoxime of tetrahydro benzothiazol 7： Medicine also includes above-mentioned cis-trans-isomer pharmaceutically acceptable salt (HX).Specific preparation process is that the cyclohexanedione (raw material 1) of 2 bromo 1,3 and thioamides flow back overnight under conditions of ethanol as solvent, obtains the ketone of 2 substituted-tetrahydro benzothiazole 7 (intermediate 2)；Intermediate 2 and hydroxylamine hydrochloride are flowed back in anhydrous ethanol solvent under the effect of glacial acetic acid sodium, the ketoxime of 2 substituted-tetrahydro benzothiazole 7 (intermediate 3) is obtained；Intermediate 3 and propargyl bromide are dissolved in anhydrous acetonitrile, in the presence of sodium hydride, stirring reaction obtains the ketoxime ether of 2 substituted-tetrahydro benzothiazole 7 (intermediate 4)；Intermediate 4 is made into catalyst in CuI and obtains the ketoxime class medicine of tetrahydro benzothiazol 7 with 1,3 Dipolar Cycloadditions of azide intermediate generation.And be applied in preparation treatment anti-gastric cancer medicament. |
| priorityDate | 2015-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.