| abstract |
The present invention discloses a class XPO1 protein inhibitors, the structure with formula F.Solubility of the XPO1 protein inhibitors of the present invention in water is very good, with raphanin as representative, such compound is high to the inhibitory activity of XPO1 albumen, and side effect is minimum, biological safety and bioavilability are good, it is very suitable for clinical practice, therefore with the huge potential of market and economic benefit. |