| abstract |
The present invention relates to ethynyl derivatives serving or its medicinal acid addition salt of formula (I), racemic mixture, or its corresponding enantiomer and/or optical isomer and/or stereoisomer, wherein Y is N or CH, R 1 It is fluorine or chlorine, R 2 It is hydrogen or methyl.Surprisingly, it is found that now that compounds of formula I is metabotropic glutamate receptor antagonists (negative allosteric modulators), it may be used for treating anxiety and pain, depression, fragile X syndrome, autism spectrum disorder, parkinson disease and gastro-esophageal reflux disease (GERD). |