http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104707149-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
| filingDate | 2013-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104707149-B |
| titleOfInvention | A kind of suicide gene nano-micelle and its preparation method and application |
| abstract | The present invention provides a kind of suicide gene nano-micelles, including amphipathic triblock polymer and suicide gene, the suicide gene nano-micelle is the complex with three-decker, the poly- leucine constitutes the internal layer of the complex, the polylysine constitutes the middle layer of the complex, and the amino-polyethyleneglycols carboxylic acid constitutes the outer layer of the complex；Wherein, the middle layer of the complex further includes suicide gene plasmid, and the suicide gene plasmid is dispersed in the polylysine of middle layer.The suicide gene nano-micelle uses biocompatibility and the preferable triblock polymer of stability to prepare suicide gene vector for carrier material, the carrier can load suicide gene plasmid well, transfection efficiency is higher, the stability of suicide gene plasmid in vivo can be improved, the half-life period of suicide gene plasmid in vivo is extended；The present invention also provides a kind of preparation method and application of suicide gene nano-micelle. |
| priorityDate | 2013-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 327.