http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104703983-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2013-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104703983-B |
| titleOfInvention | The double diamine derivatives of (4 (base of piperazine 1) phenyl) pyrimidine 2,4 of N2, N4 or its pharmaceutically acceptable salt, and using it as active component for prevention or the composition for the treatment of cancer |
| abstract | The invention discloses a kind of new N2, the double diamine derivatives of (4 (base of piperazine 1) phenyl) pyrimidine 2,4 of N4 or its pharmaceutically acceptable salt, and as active component for prevention or the pharmaceutical composition for the treatment of cancer.The compounds of this invention has good inhibition to the activity of anaplastic lymphoma kinase (ALK) and the Cdc42 associated kinases (ACK1) of activation, it can thus improve to the therapeutic effect with anaplastic lymphoma kinase fusion protein such as EML4 ALK and NPM ALK cancer cell, and also effectively prevent cancer, thus as the pharmaceutical composition for being used to prevent and treat cancer be useful. |
| priorityDate | 2012-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 852.