http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104693219-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104693219-B |
| titleOfInvention | With Diclofenac copper complex for suppressing urease activity and preparation method thereof |
| abstract | There is Diclofenac copper complex for suppressing urease activity and preparation method thereof the present invention relates to three kinds, belong to complex synthesis and field of pharmaceutical chemistry technology.Three kinds of complexs that the present invention is provided ion centered on copper ion：Complex 1 is part with Diclofenac and 1,3 propane diamine, is a dual-core architecture；Complex 2, with Diclofenac and imidazoles as part, is a structure；Complex 3, for part, is a mononuclear structure with Diclofenac and 2,2' bipyridyl.Find after tested, complex of the present invention 1,2,3 suppresses the IC of urase 50 Value is respectively 0.132,0.25,0.448 μ Mol/L, the inhibiting rate to urease activity reaches 50%, positive control N hydroxyl acetamides IC 50 Be worth is 12.5 μ Mol/L, complex of the present invention suppresses urease activity and is superior to positive control, is a kind of good urease inhibitor. |
| priorityDate | 2015-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.