| abstract |
The present invention relates to the compositions and method conveyed for oxygen.H NOX albumen, which is sported, shows improvement or optimization blood gas O 2 Convey dynamics and macroscopic property.Engineering H NOX albumen includes mutation, and the mutation assigns the O changed compared with corresponding wild type H NOX structural domains 2 Or NO ligand bindings, and can be as the mammalian O of PHYSIOLOGICALLY COMPATIBLE 2 Carrier gas works.Present invention provides pharmaceutical composition, kit and methods, they convey O using wild type or mutation H NOX albumen for treating 2 Any illness beneficial to its. |