http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104688750-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 |
| filingDate | 2015-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104688750-B |
| titleOfInvention | A kind of purposes of polygonin in preparing anti-arrhythmia product |
| abstract | The present invention relates to the purposes of Gentrin Knotweed P.E polygonin.Myocardial hypertrophy is then the most important reason for causing heart failure.Ventricular hypertrophy is usually directed to ventricular structure change, i.e. remodeling ventricle.Myocardial remodelling is the complication of many angiocardiopathies, is the important determinant in heart failure evolution.Incidence of arrhythmia improves 28 ﹪ after myocardial remodelling, and cardiac sudden death is finally caused to increase 5 times or more.It tests and shows through in vitro study, polygonin significantly inhibits the reconstruct of the cardiac ion channel caused by mouse ischemic injuries, has stronger protective effect to arrhythmia cordis, thus polygonin can be used for preparing anti-myocardial hypertrophy and/or ventricular hypertrophy institute proarrhythmia product.In the present invention, polygonin shortens Single Cardiac Cell time-histories (APD), inhibits QT interval prolongations, play antiarrhythmic effect by increasing Transient Outward Potassium Current (Ito) current density. |
| priorityDate | 2015-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 141.