http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104672462-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 2015-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104672462-B |
| titleOfInvention | A kind of multiple tooth bionical ligand for enhancing nano-particle biocompatibility and stability and preparation method thereof |
| abstract | The present invention provides a kind of multiple tooth bionical ligand for enhancing nano-particle biocompatibility and stability and preparation method thereof.The bionical ligand of synthesis by end is the alkoxy polyethylene glycol singly blocked of hydroxyl or carboxyl, the carboxylic acid group of carboxylic acid compound with catechol group is coupled to form respectively with the amino of Chitosan poly oligosaccharide.Since there are three kinds of different interface interaction power between bionical ligand and nano-particle：It is combined including catechol group with the coordination of metal; both sexes structure forms the electrostatic attraction between micella Encapsulation nanoparticle, the positive charge and nano-particle that ligand carries; therefore; by cause interface different role power and nano-particle surface carry out it is self-assembled modified; so as to prepare one layer of fine and close protective film in particle surface; nano particle can be transferred in water phase, obtain the nano-particle of good dispersion and stability.The water soluble nanometer particles that the present invention obtains can be applied to the bio-imagings fields such as magnetic resonance imaging (MRI) contrast agent. |
| priorityDate | 2015-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.