| abstract |
A method for synthesizing 3-fluoroquinoline derivatives: starting from simple 3-nitroquinoline, using Bronsted acid as a catalyst, replacing 1,4-dihydropyridine (HEH) as a reducing agent, and realizing quinoline The 1,4-reduction of the enamine gives the enamine, and the enamine intermediate is electrophilicly added to the fluorinating reagent, and then re-aromatized under alkaline conditions, which can be derived from various substituted 3-fluoroquinolines things. The invention is simple and practical in operation, easy to obtain raw materials, fast in reaction, convenient in aftertreatment and high in yield. |