http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104672105-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-43 |
| filingDate | 2015-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104672105-B |
| titleOfInvention | The preparation method of L-3-(3,4-Dimethoxyphenyl)-2-amino-2-methyl propionitrile hydrochlorate |
| abstract | The present invention relates to technical field of medical chemistry, it is desirable to provide the preparation method of a kind of L 3 (3,4 Dimethoxyphenyl) 2 amino 2 methyl propionitrile hydrochlorate.The method is: veratone, Cyanogran., ammonium chloride and ammonia is added in reactor, then passes to ammonia；Reaction is lowered the temperature after terminating, centrifugation, obtains D, L aminopropionitrile；It is dissolved in organic solvent, addition L (+) 2,3 dyhydrobutanedioic acids, stirring reaction；Adding hydrochloric acid stirring, cooling is centrifuged separating treatment, obtains L 3 (3,4 Dimethoxyphenyl) 2 amino 2 methyl propionitrile hydrochlorate.Veratone conversion ratio in the inventive method is high, can reach 90～95%.Repeatedly apply mechanically many times after produced ammonia mother liquid in reaction, organic solvent are recyclable, decrease the pollution to environment.(3) reaction employs solvent and replace water, thoroughly decrease the discharge of sewage.Resolving agent consumption can reduce half, splits effective simultaneously；Without regulating the complex operations such as pH value, stable preparation process, easily operate. |
| priorityDate | 2015-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.