| abstract |
The present invention relates to a kind of LncRNA, oncolytic adenovirus of competitive consumption carcinogenicity microRNAs (OncomiRs) and application thereof.The present invention it is artificial synthesized can the various OncomiRs of Combination intervention LncRNA coded sequence, it is the vector expression LncRNA with oncolytic adenovirus, and using the Survivin Gene Promoters oncolytic adenovirus propagation indispensable gene E1a of tumour-specific, virus is set to be replicated in cancer cell proliferated specifically inside, replicated in cancer cell internal specific copy high with adenovirus, realize LncRNA great expression and copy accumulation high in cancer cell, by the target gene competitive binding with OncomiRs and consume OncomiRs, so as to protect substantial amounts of tumor suppressor gene from the interference and suppression of OncomiRs, realize the targeting therapeutic intervention to cancer cell, possesses good effect, safe advantage. |