http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104650244-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104650244-B |
| titleOfInvention | A kind of epitope combined peptide with hypoglycemic simultaneous Regulation serum lipids and application thereof |
| abstract | The invention provides a kind of double epitope peptides with Regulation serum lipids and the type 1 diabetes blood glucose value that can reduce STZ inductions.The B cell antigen epi-position of diabetic complication GAP-associated protein GAP HMG COA reductases is analyzed with B cell antigen epi-position analysis software and on-line analysis instrument, the B epitope peptide HGRWIADPSPQNSTT of acquisition is connected with the anti-type 1 diabetes T epitope peptides in P277 PEPCs end, 28 peptide H278P are obtained, its sequence is：HGRWIADPSPQNSTTIPALDSLTPANED, fat can be adjusted by dorsal sc immunization route and reduce the type 1 diabetes blood glucose value of the C57BL/6J mouse of STZ inductions, epitope combined peptide provided by the invention can be used for recombinant microorganism and transgenic animals or plant simultaneously, make them as production plant, the peptide can be produced or make oral vaccine, it can be used for hypoglycemic and adjust blood fat, and available for the prevention or treatment of diabetes, high fat of blood, atherosclerosis, cardiovascular and cerebrovascular disease. |
| priorityDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 180.