http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104650112-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 |
| filingDate | 2013-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104650112-B |
| titleOfInvention | The preparation method of tacrolimus 8- propyl analogs |
| abstract | The invention discloses the preparation method of 8 propyl analog of tacrolimus, the separation for tacrolimus impurity prepares, includes the following steps：A, dissolution filter：By tacrolimus raw material organic solvent and water dissolution, filtering is configured to sample solution, and the organic solvent is selected from one or more of methanol, ethyl alcohol and acetonitrile；B, prepared by separation：Chromatography retention behavior shown by relative retention time according to impurity determines the condition of preparative chromatography, and the corresponding impurity of retention time is collected with preparative chromatography；C, drying：By the component being collected into step B vacuum distillation and desivac drying, the impurity after drying carries out HPLC detections；D, the impurity product obtained in step C is subjected to LC MS detections. |
| priorityDate | 2013-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.