| abstract |
The present invention provides a class of substituted heteroaryl compounds and their compositions and uses. The compound is a compound represented by formula (I) or a stereoisomer, tautomer, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The present invention also provides a pharmaceutical composition comprising the compound, the compound and the pharmaceutical composition can regulate the activity of JAK kinase, and are used for preventing, treating, treating and alleviating JAK-mediated diseases or disorders. |