http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104644573-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2015-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104644573-B |
| titleOfInvention | Carry arsenic trioxide pH response mesoporous silicon dioxide nano particles and preparation method thereof |
| abstract | The preparation method that arsenic trioxide pH responds mesoporous silicon dioxide nano particle is carried the invention discloses a kind of, mainly preparing amino modified mesoporous silicon oxide, Electrostatic Absorption including coprecipitation is loaded into the step of ATO, PAA acid-base conjugate prepare PAA ATO MSNs.Outward appearance is rounded under PAA ATO MSNs transmission electron microscopes prepared by the present invention or similar round, and average grain diameter is（158.6±1.32）Nm, Zeta Current potential is（‑28.40±0.34）MV, envelop rate and drugloading rate are respectively（40.95±3.21）%,（11.42±1.75）%.Tablets in vitro has pH responses, and cumulative release amount reduces and increased with pH.Pharmacokinetic studies show, compared with ATO Sol and ATO MSNs, PAA ATO MSNs t 1/2β Significantly extension, AUC is significantly increased（P<0.01）.PAA ATO MSNs tablets in vitro has obvious pH responses and slow release characteristic, can be obviously improved rat Internal pharmacokinetics behavior, and the carrier has preferable application prospect as ATO cancer target delivery systems. |
| priorityDate | 2015-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.