http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104623697-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 |
| filingDate | 2015-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104623697-B |
| titleOfInvention | Method for preparing polymeric micelle type magnetic resonance contrast agent based on human physiological temperature response |
| abstract | The invention belongs to technical field of a method for preparing a nanometer polymer material and specifically discloses a method for preparing a polymeric micelle type magnetic resonance contrast agent based on human physiological temperature response. The contrast agent is designed with a polymer chain segment of polyisopropylacrylamide and polymethacrylate for improving and modifying the CEST contrast agent by means of a chemical exchange saturation transfer CEST imaging method, and a temperature sensitive polymeric micelle of a core-shell structure is prepared. A mixed self-assembly method of long and short chains is used for regulating the lower critical solution temperature LCST value to be close to the human physiological temperature, and the contrast agent has magnetic resonance signal response with high sensitivity at the human physiological temperature, so that change enhancement based on temperature of the magnetic resonance signal can be obtained, and excellent magnetic resonance development capacity is provided for the detection of human microenvironment. |
| priorityDate | 2015-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.