http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104610253-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104610253-B |
| titleOfInvention | 2 trifluoromethyl 2 hydroxyl 2 (2 aryl-pyridines also [1,2 α] imidazoles) acetate compounds |
| abstract | The invention discloses a kind of 2 trifluoromethyl 2 hydroxyls 2 (2 aryl-pyridines also [1,2 α] imidazoles) propionic acid ester compound extremely preparation method, under the conditions of anhydrous and oxygen-free, by 2 aryl-pyridines also [1,2 α] imidazoles and trifluoroacetone acid esters add in reaction vessel, add Di Iso Propyl Ether, by reaction bulb under ar gas environment, 0 ~ 60 DEG C react 10 ~ 48 hours；Reaction terminates rear concentrating under reduced pressure, carries out chromatographic isolation, obtains target product.Use the mode of trifluoromethyl building block, synthesize in the common trifluoromethyl functional group of field of medicaments, gained compound, with hydroxyl, aliphatic radical, facilitates further salt-forming reaction, application for later medicine direction solves solubility problem, pyrido [1,2 α] imidazole group in gained compound structure has good pharmaceutically active, and this reaction does not use metallic catalyst and additive, it is prone to purification, with low cost. |
| priorityDate | 2015-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.