http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104606127-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104606127-B |
| titleOfInvention | The load platinum medicine albumin nano granular of targeting EGFR and its preparation and application |
| abstract | The invention belongs to field of pharmaceutical preparations, it is related to a kind of platinum medicine albumin nano preparation of target recognition of tumor cell EGFR acceptors.The present invention is decentralized crosslinking agent, using amination EGFR aptamers as targeting modification molecule with albumin load platinum medicine, with medical polyethylene glycol (PEG), and soluble albumin nano (Apt PtNPs) preparation is made.The nanoparticle can specifically bind with the EGF-R ELISA (EGFR) of tumor cell surface and occur cell endocytic, so as to reduce the toxic side effect of platinum medicine, reach the purpose of attenuation synergistic, and can be by promoting EGFR protein phosphorylations to suppress EGFR expression, and then play collaboration platinum medicine antitumous effect.Available for the preparation of antineoplastic, prove, the nanoparticle targeting is good, lethal effect is strong that there is good application prospect in therapy of tumor and chemotherapy drugs in combination treatment especially in the Therapy study of cervical carcinoma and oophoroma. |
| priorityDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.