| abstract |
The invention discloses a class of novel derivatives of piperine, their preparation method and application. The derivatives have the structure shown in general formula I. In formula I, Linker is an alkyl group with different lengths, degrees of unsaturation and positions of covalent bonds chain, specifically carbonyl, 1-vinyl, 1-butenyl, 3-butenoyl, 3,5-hexenoyl, 5-hexenoyl, 5,7-octenyl or 1,5,7 -octenoyl. A class of derivatives of the present invention has good antitumor activity, and can be used clinically by oral administration, intravenous injection, intramuscular injection and the like. |