| abstract |
The invention discloses 1,3,5-trisubstituted pyrazole compounds and their preparation method and application, the structure of which is shown in general formula (I): Wherein, R is hydrogen, halogen, methyl or trifluoromethyl; R is methyl, ethyl, n - propyl, isopropyl, cyclopropyl or an aliphatic hydrocarbon chain or ring with 4-8 carbons; R 3 , R 4 , R 5 , R 6 or R 7 are hydrogen, halogen, methyl, trifluoromethyl, methoxy, trifluoromethoxy, ethynyl, nitro or nitrile; X is carbonyl, Amide groups, urea, thiourea. The 1,3,5-trisubstituted pyrazole compounds of the present invention, especially 8aM06, 8aM21, 8aM23, 8aM25, 8aM26, 8aE02, 8aE08, 8aE10, 8eE01 and 8cE01 have strong effects on prostate cancer cells LNCaP and PC-3 The cell growth inhibitory activity can be used to prepare antitumor drugs. |