http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104561172-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10 |
| filingDate | 2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104561172-B |
| titleOfInvention | A kind of method of lipase-catalyzed online synthesis laurate 1 (4 nitroimidazole base) ethyl ester |
| abstract | The invention discloses a kind of method of lipase-catalyzed online synthesis laurate 1 (4 nitroimidazole base) ethyl ester, methods described is：The ratio between amount with material is 1:1~8 4 nitroimidazoles are raw material with vinyl laurate, using 0.5~1.0g Lipozymes TLIM as catalyst, using DMSO solvents as reaction dissolvent, in the reaction channel that Lipozyme TLIM is uniformly filled in microfluidic channel reactor, the reaction channel internal diameter of the microfluidic channel reactor is 0.8~2.4mm, a length of 0.5~1.0m of reaction channel；Raw material and reaction dissolvent is set continuously to be passed through progress Markovnikov addition reaction in reaction channel, controlling reaction temperature is 40~55 DEG C, reaction time is 20~35min, and reaction solution is collected online, and reaction solution obtains laurate 1 (4 nitroimidazole base) ethyl ester through conventional post processing.The present invention has the advantages that the reaction time is short, selectivity is high and yield is high. |
| priorityDate | 2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.