| abstract |
The present invention discloses novel ApoE peptide derivatives and ApoE-protein transduction domain conjugates useful for the treatment of diseases including CNS inflammation, traumatic brain injury, inflammatory bowel disease (also known as segmental or ulcerative colitis), cerebral ischemia, atherosclerosis, sepsis, multiple sclerosis and arthritic diseases, alzheimer's disease and other brain diseases. The present invention includes methods of protecting a subject undergoing irradiation or radiotherapy by administration of ApoE or at least one ApoE mimetic peptide. |