http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104558117-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104558117-B |
| titleOfInvention | A kind of D configurations polypeptide of acetylcholine receptor mediated targeting and its application |
| abstract | The invention belongs to pharmaceutical field, be related to it is a kind of highly stable and can mediated targeted acetyl choline receptor high expressing cell, and across the D configurations polypeptide and its nanoscale medicine delivery system of corresponding barrier film, and inside and outside brain targeting and the application in the diseases such as treatment brain.Shown through result of the test： D CDX and acetylcholinergic receptor combination IC 50 For 84.5nM, stable and tolerance protein enzyme the hydrolysis in serum； D Model drug entrained by CDX is expressed the positive cell specificity intake of acetylcholinergic receptor, has the ability that barrier is formed across such cell； D Package-contained model drug can be delivered to target tissue by the nanoscale medicine delivery system constructed by the polymer carrier of CDX modifications, and significantly improve effect of drugs.The D configuration polypeptides of the present invention D CDX can mediate drug or nanoscale medicine delivery system active target-seeking, possess good application prospect in the diagnosis and treatment of a variety of diseases. |
| priorityDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.