abstract |
The invention belongs to the field of chemical medicine, and relates to a pyrrolopyrazine compound hydrochloride and its application, in particular to a pyrrolopyrazine compound having BCR-ABL kinase inhibitory activity, and a pharmaceutical composition containing the compound and Application of the compound or composition in medicine preparation. The pyrrolopyrazine compound provided by the present invention has a very significant inhibitory effect on various tumor cells, including T315I mutation and drug-resistant leukemia cells, and also exhibits good stability, solubility and oral bioavailability. |